दवाओं की अंतःक्रिया
Benzhydrocodone / acetaminophen + Imatinib
गंभीरता: गंभीर
Benzhydrocodone / acetaminophen and Imatinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Benzhydrocodone is a prodrug of hydrocodone, which is metabolised by CYP3A4 to norhydrocodone. Imatinib inhibits CYP3A4, which can raise hydrocodone levels and increase sedation and respiratory depression.
इस इंटरैक्शन का सरल भाषा में अर्थ
Benzhydrocodone / acetaminophen and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
CYP3A4 inhibition by imatinib reduces hydrocodone clearance, with a minor contribution from CYP2D6 inhibition.
क्या करें
Monitor closely for sedation and respiratory depression, and reduce the opioid dose if needed. Take care when imatinib is started or stopped.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Benzhydrocodone / acetaminophen और Imatinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Imatinib के अन्य इंटरैक्शन
- Imatinib + Lomitapide निषिद्ध
- Imatinib + Lonafarnib निषिद्ध
- Amobarbital + Imatinib गंभीर
- Apalutamide + Imatinib गंभीर
- Avapritinib + Imatinib गंभीर
- Bosutinib + Imatinib गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Benzhydrocodone / acetaminophen with Imatinib?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Imatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is a prodrug of hydrocodone, which is metabolised by CYP3A4 to norhydrocodone. Imatinib inhibits CYP3A4, which can raise hydrocodone levels and increase sedation and respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Imatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for sedation and respiratory depression, and reduce the opioid dose if needed. Take care when imatinib is started or stopped.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
