दवाओं की अंतःक्रिया
Axicabtagene ciloleucel + Azathioprine
गंभीरता: गंभीर
Axicabtagene ciloleucel and Azathioprine: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
इस इंटरैक्शन का सरल भाषा में अर्थ
Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Azathioprine belongs to Gastrointestinal Tract.
ऐसा क्यों होता है
Immunosuppressive antimetabolite activity against lymphocytes may reduce CAR-T cell expansion and persistence.
क्या करें
Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Axicabtagene ciloleucel और Azathioprine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Azathioprine के अन्य इंटरैक्शन
- Adenovirus types 4 and 7 live + Azathioprine निषिद्ध
- Azathioprine + Bcg vaccine live निषिद्ध
- Azathioprine + Febuxostat निषिद्ध
- Azathioprine + Influenza virus vaccine quadrivalent intranasal निषिद्ध
- Azathioprine + Measles mumps and rubella vaccine निषिद्ध
- Azathioprine + Measles mumps and rubella vaccine live निषिद्ध
Axicabtagene ciloleucel के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Axicabtagene ciloleucel with Azathioprine?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Azathioprine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azathioprine may impair T-cell function and reduce CAR-T cell expansion and efficacy. Concurrent immunosuppression also adds to infection risk after lymphodepletion.
How serious is the interaction between Axicabtagene ciloleucel and Azathioprine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue azathioprine before leukapheresis and infusion as advised by the treating CAR-T center. Monitor for infections if immunosuppression cannot be stopped.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
