दवाओं की अंतःक्रिया
Azathioprine + Febuxostat
गंभीरता: निषिद्ध
Azathioprine and Febuxostat: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
इस इंटरैक्शन का सरल भाषा में अर्थ
Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Febuxostat belongs to Genitourinary.
ऐसा क्यों होता है
Febuxostat inhibits xanthine oxidase, which is needed to inactivate 6-mercaptopurine, leading to accumulation of active thiopurine metabolites.
क्या करें
Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Azathioprine और Febuxostat की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
- Febuxostat (Uloric) Prescribing Information - Drug Interactions — FDA Label
- Adenuric (febuxostat) Summary of Product Characteristics — EMA SmPC
Febuxostat के अन्य इंटरैक्शन
- Febuxostat + Mercaptopurine निषिद्ध
- Didanosine + Febuxostat गंभीर
- Apalutamide + Febuxostat मध्यम
- Ethambutol + Febuxostat मध्यम
- Febuxostat + Theophylline मध्यम
Azathioprine के अन्य इंटरैक्शन
- Adenovirus types 4 and 7 live + Azathioprine निषिद्ध
- Azathioprine + Bcg vaccine live निषिद्ध
- Azathioprine + Influenza virus vaccine quadrivalent intranasal निषिद्ध
- Azathioprine + Measles mumps and rubella vaccine निषिद्ध
- Azathioprine + Measles mumps and rubella vaccine live निषिद्ध
- Azathioprine + Measles mumps rubella and varicella vaccine live निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Azathioprine with Febuxostat?
MediHelp rates the interaction as contraindicated. Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
How serious is the interaction between Azathioprine and Febuxostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Mercaptopurine, Didanosine, Apalutamide. The full list is on the Febuxostat page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
