दवाओं की अंतःक्रिया
Axicabtagene ciloleucel + Tofacitinib
गंभीरता: गंभीर
Axicabtagene ciloleucel and Tofacitinib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Tofacitinib's immunosuppression may impair CAR-T expansion and efficacy, and adds to the infection risk that follows lymphodepletion and CAR-T therapy. Prior use of immunosuppressants is generally minimized around infusion.
इस इंटरैक्शन का सरल भाषा में अर्थ
Axicabtagene ciloleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
ऐसा क्यों होता है
JAK inhibition suppresses T-cell signalling and may reduce CAR-T activity, with additive immunosuppression.
क्या करें
Hold tofacitinib around leukapheresis and infusion as advised by the treating team. Monitor closely for infection.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Axicabtagene ciloleucel और Tofacitinib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Tofacitinib के अन्य इंटरैक्शन
Axicabtagene ciloleucel के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Axicabtagene ciloleucel with Tofacitinib?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tofacitinib's immunosuppression may impair CAR-T expansion and efficacy, and adds to the infection risk that follows lymphodepletion and CAR-T therapy. Prior use of immunosuppressants is generally minimized around infusion.
How serious is the interaction between Axicabtagene ciloleucel and Tofacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold tofacitinib around leukapheresis and infusion as advised by the treating team. Monitor closely for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
