दवाओं की अंतःक्रिया
Azathioprine + Denosumab
गंभीरता: मध्यम
Azathioprine and Denosumab: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
इस इंटरैक्शन का सरल भाषा में अर्थ
Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Denosumab belongs to Oncology.
ऐसा क्यों होता है
Additive pharmacodynamic effects on immune function; denosumab inhibits RANKL signalling while azathioprine impairs purine synthesis in lymphocytes.
क्या करें
Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Azathioprine और Denosumab की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Azathioprine के अन्य इंटरैक्शन
- Adenovirus types 4 and 7 live + Azathioprine निषिद्ध
- Azathioprine + Bcg vaccine live निषिद्ध
- Azathioprine + Febuxostat निषिद्ध
- Azathioprine + Influenza virus vaccine quadrivalent intranasal निषिद्ध
- Azathioprine + Measles mumps and rubella vaccine निषिद्ध
- Azathioprine + Measles mumps and rubella vaccine live निषिद्ध
Denosumab के अन्य इंटरैक्शन
- Abatacept + Denosumab मध्यम
- Adalimumab + Denosumab मध्यम
- Alefacept + Denosumab मध्यम
- Alemtuzumab + Denosumab मध्यम
- Anakinra + Denosumab मध्यम
- Azacitidine + Denosumab मध्यम
अक्सर पूछे जाने वाले प्रश्न
Can I take Azathioprine with Denosumab?
MediHelp rates the interaction as moderate. Azathioprine and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab has been associated with serious infections, including skin and urinary tract infections, and the risk may be higher in patients on immunosuppressants. Azathioprine adds to this by suppressing lymphocyte proliferation, so the combination can increase infection susceptibility.
How serious is the interaction between Azathioprine and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report fever or signs of infection promptly and treat infections early. Monitor for infection and review the need for continued immunosuppression if serious infections occur.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
