दवाओं की अंतःक्रिया
Blinatumomab + Quinine
गंभीरता: मध्यम
Blinatumomab and Quinine: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Blinatumomab causes a transient cytokine release at the start of treatment that may suppress CYP450 enzyme activity. This could temporarily raise quinine concentrations, which matters because quinine has a narrow therapeutic window and cardiac toxicity.
इस इंटरैक्शन का सरल भाषा में अर्थ
Blinatumomab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Quinine belongs to Anti Parasitic.
ऐसा क्यों होता है
Cytokine-mediated transient suppression of CYP450 enzymes (including CYP3A4) reducing quinine metabolism.
क्या करें
Monitor for quinine toxicity (tinnitus, QT prolongation, hypoglycemia) during the first days of the first cycle and after re-initiation. Consider reducing the quinine dose or monitoring ECG in high-risk patients.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Blinatumomab और Quinine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Quinine के अन्य इंटरैक्शन
- Arsenic trioxide + Quinine निषिद्ध
- Dofetilide + Quinine निषिद्ध
- Dronedarone + Quinine निषिद्ध
- Ibutilide + Quinine निषिद्ध
- Mefloquine + Quinine निषिद्ध
- Nilotinib + Quinine निषिद्ध
Blinatumomab के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Blinatumomab with Quinine?
MediHelp rates the interaction as moderate. Blinatumomab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at the start of treatment that may suppress CYP450 enzyme activity. This could temporarily raise quinine concentrations, which matters because quinine has a narrow therapeutic window and cardiac toxicity.
How serious is the interaction between Blinatumomab and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity (tinnitus, QT prolongation, hypoglycemia) during the first days of the first cycle and after re-initiation. Consider reducing the quinine dose or monitoring ECG in high-risk patients.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
