Drug interactions
Blinatumomab + Quinine
Severity: Moderate
Blinatumomab and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes a transient cytokine release at the start of treatment that may suppress CYP450 enzyme activity. This could temporarily raise quinine concentrations, which matters because quinine has a narrow therapeutic window and cardiac toxicity.
What this interaction means in plain words
Blinatumomab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated transient suppression of CYP450 enzymes (including CYP3A4) reducing quinine metabolism.
What to do
Monitor for quinine toxicity (tinnitus, QT prolongation, hypoglycemia) during the first days of the first cycle and after re-initiation. Consider reducing the quinine dose or monitoring ECG in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Cyclosporin Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Siponimod Moderate
Frequently asked questions
Can I take Blinatumomab with Quinine?
MediHelp rates the interaction as moderate. Blinatumomab and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at the start of treatment that may suppress CYP450 enzyme activity. This could temporarily raise quinine concentrations, which matters because quinine has a narrow therapeutic window and cardiac toxicity.
How serious is the interaction between Blinatumomab and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity (tinnitus, QT prolongation, hypoglycemia) during the first days of the first cycle and after re-initiation. Consider reducing the quinine dose or monitoring ECG in high-risk patients.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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