दवाओं की अंतःक्रिया
Cabozantinib + Posaconazole
गंभीरता: गंभीर
Cabozantinib and Posaconazole: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
ऐसा क्यों होता है
Strong CYP3A4 inhibition by posaconazole reduces the metabolic clearance of cabozantinib.
क्या करें
Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cabozantinib और Posaconazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Posaconazole के अन्य इंटरैक्शन
- Artemether + Posaconazole निषिद्ध
- Avanafil + Posaconazole निषिद्ध
- Cobimetinib + Posaconazole निषिद्ध
- Conivaptan + Posaconazole निषिद्ध
- Dihydroergotamine intranasal + Posaconazole निषिद्ध
- Dihydroergotamine + Posaconazole निषिद्ध
Cabozantinib के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Cabozantinib with Posaconazole?
MediHelp rates the interaction as major. Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
How serious is the interaction between Cabozantinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
