Drug interactions
Cabozantinib + Posaconazole
Severity: Major
Cabozantinib and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
What this interaction means in plain words
Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces the metabolic clearance of cabozantinib.
What to do
Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Posaconazole?
MediHelp rates the interaction as major. Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
How serious is the interaction between Cabozantinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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