दवाओं की अंतःक्रिया
Canagliflozin-metformin + Trilaciclib
गंभीरता: गंभीर
Canagliflozin-metformin and Trilaciclib: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
इस इंटरैक्शन का सरल भाषा में अर्थ
Canagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Canagliflozin-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
ऐसा क्यों होता है
Inhibition of renal OCT2 and MATE1/MATE2-K transporters reduces metformin elimination.
क्या करें
Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Canagliflozin-metformin और Trilaciclib की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Canagliflozin-metformin के अन्य इंटरैक्शन
Trilaciclib के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Canagliflozin-metformin with Trilaciclib?
MediHelp rates the interaction as major. Canagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
