Drug interactions
Canagliflozin-metformin + Trilaciclib
Severity: Major
Canagliflozin-metformin and Trilaciclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Canagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Canagliflozin-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
Why it happens
Inhibition of renal OCT2 and MATE1/MATE2-K transporters reduces metformin elimination.
What to do
Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Trilaciclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Trilaciclib
Frequently asked questions
Can I take Canagliflozin-metformin with Trilaciclib?
MediHelp rates the interaction as major. Canagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
