दवाओं की अंतःक्रिया
Capecitabine + Leucovorin
गंभीरता: गंभीर
Capecitabine and Leucovorin: major interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Leucovorin stabilizes the binding of the active fluorouracil metabolite to thymidylate synthase, which enhances the cytotoxic effect of fluoropyrimidines. This can increase toxicities of capecitabine such as diarrhea, mucositis, hand-foot syndrome and myelosuppression.
इस इंटरैक्शन का सरल भाषा में अर्थ
Capecitabine and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capecitabine belongs to Oncology; Leucovorin belongs to Miscellaneous.
ऐसा क्यों होता है
Leucovorin increases reduced folate pools, stabilizing the fluorodeoxyuridylate-thymidylate synthase complex and potentiating fluoropyrimidine activity.
क्या करें
Avoid combining unless it is part of a specifically designed regimen, as capecitabine labeling advises caution. If used, monitor closely for severe diarrhea and myelosuppression and reduce the capecitabine dose as needed.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Capecitabine और Leucovorin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Capecitabine के अन्य इंटरैक्शन
Leucovorin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Capecitabine with Leucovorin?
MediHelp rates the interaction as major. Capecitabine and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leucovorin stabilizes the binding of the active fluorouracil metabolite to thymidylate synthase, which enhances the cytotoxic effect of fluoropyrimidines. This can increase toxicities of capecitabine such as diarrhea, mucositis, hand-foot syndrome and myelosuppression.
How serious is the interaction between Capecitabine and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless it is part of a specifically designed regimen, as capecitabine labeling advises caution. If used, monitor closely for severe diarrhea and myelosuppression and reduce the capecitabine dose as needed.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
