दवाओं की अंतःक्रिया
Fluorouracil + Leucovorin
गंभीरता: गंभीर
Fluorouracil and Leucovorin: major interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
इस इंटरैक्शन का सरल भाषा में अर्थ
Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluorouracil belongs to Oncology; Leucovorin belongs to Miscellaneous.
ऐसा क्यों होता है
Leucovorin supplies reduced folate that stabilizes the binding of fluorodeoxyuridylate to thymidylate synthase, enhancing both efficacy and toxicity.
क्या करें
Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Fluorouracil और Leucovorin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Fluorouracil के अन्य इंटरैक्शन
Leucovorin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Fluorouracil with Leucovorin?
MediHelp rates the interaction as major. Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
How serious is the interaction between Fluorouracil and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
