दवाओं की अंतःक्रिया
Cladribine + Siponimod
गंभीरता: निषिद्ध
Cladribine and Siponimod: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cladribine causes prolonged lymphocyte depletion, and siponimod further reduces lymphocyte counts. Combined use may produce profound, long-lasting immunosuppression with serious infection risk.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cladribine and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cladribine belongs to Oncology; Siponimod belongs to Central Nervous System.
ऐसा क्यों होता है
Additive lymphocyte depletion: cladribine is cytotoxic to lymphocytes and siponimod sequesters them in lymphoid tissue.
क्या करें
Do not use together; cladribine labeling advises against concomitant immunosuppressive or myelosuppressive therapy. When switching, check lymphocyte counts and allow adequate recovery before starting the second drug.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cladribine और Siponimod की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Siponimod के अन्य इंटरैक्शन
Cladribine के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Cladribine with Siponimod?
MediHelp rates the interaction as contraindicated. Cladribine and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cladribine causes prolonged lymphocyte depletion, and siponimod further reduces lymphocyte counts. Combined use may produce profound, long-lasting immunosuppression with serious infection risk.
How serious is the interaction between Cladribine and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; cladribine labeling advises against concomitant immunosuppressive or myelosuppressive therapy. When switching, check lymphocyte counts and allow adequate recovery before starting the second drug.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Fingolimod, Fluconazole, Influenza virus vaccine quadrivalent intranasal. The full list is on the Siponimod page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
