दवाओं की अंतःक्रिया
Siponimod + Thioridazine
गंभीरता: निषिद्ध
Siponimod and Thioridazine: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.
इस इंटरैक्शन का सरल भाषा में अर्थ
Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Siponimod belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
ऐसा क्यों होता है
Siponimod-induced heart rate slowing combined with thioridazine-induced QT prolongation increases torsades risk.
क्या करें
Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Siponimod और Thioridazine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Thioridazine के अन्य इंटरैक्शन
- Abiraterone + Thioridazine निषिद्ध
- Adagrasib + Thioridazine निषिद्ध
- Amiodarone + Thioridazine निषिद्ध
- Amisulpride + Thioridazine निषिद्ध
- Amitriptyline + Thioridazine निषिद्ध
- Amoxapine + Thioridazine निषिद्ध
Siponimod के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Siponimod with Thioridazine?
MediHelp rates the interaction as contraindicated. Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.
How serious is the interaction between Siponimod and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
