दवाओं की अंतःक्रिया
Clomipramine + Cocaine
गंभीरता: गंभीर
Clomipramine and Cocaine: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and clomipramine has similar actions on serotonin and norepinephrine. The combination can increase sympathomimetic and serotonergic effects, including hypertension, arrhythmias and serotonin toxicity. Topical use at a clinical dose has lower systemic exposure, but significant absorption can occur from mucosal use.
इस इंटरैक्शन का सरल भाषा में अर्थ
Clomipramine and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Cocaine belongs to Central Nervous System.
ऐसा क्यों होता है
Additive monoamine reuptake inhibition, with potentiated adrenergic effects and arrhythmia risk.
क्या करें
Avoid cocaine, including recreational use, in patients taking clomipramine. If topical cocaine is required, use the minimum dose and monitor blood pressure and ECG.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Clomipramine और Cocaine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Clomipramine के अन्य इंटरैक्शन
- Arsenic trioxide + Clomipramine निषिद्ध
- Clomipramine + Dofetilide निषिद्ध
- Clomipramine + Droperidol निषिद्ध
- Clomipramine + Isocarboxazid निषिद्ध
- Clomipramine + Methylene blue निषिद्ध
- Clomipramine + Pentamidine निषिद्ध
Cocaine के अन्य इंटरैक्शन
- Cocaine + Isocarboxazid निषिद्ध
- Cocaine + Phenelzine निषिद्ध
- Cocaine + Procarbazine निषिद्ध
- Amitriptyline + Cocaine गंभीर
- Bisoprolol + Cocaine गंभीर
- Citalopram + Cocaine गंभीर
अक्सर पूछे जाने वाले प्रश्न
Can I take Clomipramine with Cocaine?
MediHelp rates the interaction as major. Clomipramine and Cocaine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of norepinephrine, dopamine and serotonin, and clomipramine has similar actions on serotonin and norepinephrine. The combination can increase sympathomimetic and serotonergic effects, including hypertension, arrhythmias and serotonin toxicity. Topical use at a clinical dose has lower systemic exposure, but significant absorption can occur from mucosal use.
How serious is the interaction between Clomipramine and Cocaine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cocaine, including recreational use, in patients taking clomipramine. If topical cocaine is required, use the minimum dose and monitor blood pressure and ECG.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
