सामग्री पर जाएँ

दवाओं की अंतःक्रिया

Cocaine + Duloxetine

गंभीरता: गंभीर

Cocaine and Duloxetine: major interaction.

अंतिम अपडेट

केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।

इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।

सारांश

Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.

इस इंटरैक्शन का सरल भाषा में अर्थ

Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cocaine belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.

साक्ष्य स्तर: Low

ऐसा क्यों होता है

Additive monoamine reuptake inhibition causing serotonergic and sympathomimetic effects.

क्या करें

Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.

फार्मासिस्ट से क्या पूछें

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ सदस्यों के लिए

पूरा पेज खोलें

Cocaine और Duloxetine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।

अक्सर पूछे जाने वाले प्रश्न

Can I take Cocaine with Duloxetine?

MediHelp rates the interaction as major. Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.

How serious is the interaction between Cocaine and Duloxetine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.

What other medicines interact with Duloxetine?

MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.

MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर

MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।

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