दवाओं की अंतःक्रिया
Cyclosporin + Griseofulvin
गंभीरता: गंभीर
Cyclosporin and Griseofulvin: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Griseofulvin belongs to Anti Fungals.
ऐसा क्यों होता है
Griseofulvin induces hepatic and intestinal CYP3A4, accelerating cyclosporine metabolism.
क्या करें
Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cyclosporin और Griseofulvin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Cyclosporin के अन्य इंटरैक्शन
- Adenovirus types 4 and 7 live + Cyclosporin निषिद्ध
- Aliskiren + Cyclosporin निषिद्ध
- Bcg vaccine live + Cyclosporin निषिद्ध
- Bosentan + Cyclosporin निषिद्ध
- Cidofovir + Cyclosporin निषिद्ध
- Cyclosporin + Dengue vaccine निषिद्ध
Griseofulvin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Cyclosporin with Griseofulvin?
MediHelp rates the interaction as major. Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
How serious is the interaction between Cyclosporin and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
