दवाओं की अंतःक्रिया
Cyclosporine + Liposomal doxorubicin
गंभीरता: गंभीर
Cyclosporine and Liposomal doxorubicin: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cyclosporine inhibits P-glycoprotein and CYP3A4 and has been reported to increase doxorubicin exposure and toxicity, including myelosuppression. Cases of severe neutropenia and neurotoxicity have been reported with the combination of anthracyclines and cyclosporine. Additive immunosuppression further raises infection risk.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cyclosporine and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Cyclosporine inhibits P-gp and CYP3A4, reducing doxorubicin clearance, with additive immunosuppression.
क्या करें
Monitor blood counts, cardiac function and signs of infection closely, and consider reducing the doxorubicin dose. Avoid the combination when alternatives exist.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cyclosporine और Liposomal doxorubicin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Liposomal doxorubicin के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Cyclosporine with Liposomal doxorubicin?
MediHelp rates the interaction as major. Cyclosporine and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits P-glycoprotein and CYP3A4 and has been reported to increase doxorubicin exposure and toxicity, including myelosuppression. Cases of severe neutropenia and neurotoxicity have been reported with the combination of anthracyclines and cyclosporine. Additive immunosuppression further raises infection risk.
How serious is the interaction between Cyclosporine and Liposomal doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, cardiac function and signs of infection closely, and consider reducing the doxorubicin dose. Avoid the combination when alternatives exist.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Dronedarone. The full list is on the Liposomal doxorubicin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
