Drug interactions
Cyclosporine + Liposomal doxorubicin
Severity: Major
Cyclosporine and Liposomal doxorubicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits P-glycoprotein and CYP3A4 and has been reported to increase doxorubicin exposure and toxicity, including myelosuppression. Cases of severe neutropenia and neurotoxicity have been reported with the combination of anthracyclines and cyclosporine. Additive immunosuppression further raises infection risk.
What this interaction means in plain words
Cyclosporine and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits P-gp and CYP3A4, reducing doxorubicin clearance, with additive immunosuppression.
What to do
Monitor blood counts, cardiac function and signs of infection closely, and consider reducing the doxorubicin dose. Avoid the combination when alternatives exist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
- Ganciclovir + Liposomal doxorubicin Major
Frequently asked questions
Can I take Cyclosporine with Liposomal doxorubicin?
MediHelp rates the interaction as major. Cyclosporine and Liposomal doxorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits P-glycoprotein and CYP3A4 and has been reported to increase doxorubicin exposure and toxicity, including myelosuppression. Cases of severe neutropenia and neurotoxicity have been reported with the combination of anthracyclines and cyclosporine. Additive immunosuppression further raises infection risk.
How serious is the interaction between Cyclosporine and Liposomal doxorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, cardiac function and signs of infection closely, and consider reducing the doxorubicin dose. Avoid the combination when alternatives exist.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Dronedarone. The full list is on the Liposomal doxorubicin page.
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