दवाओं की अंतःक्रिया
Cyclosporine + Simvastatin
गंभीरता: निषिद्ध
Cyclosporine and Simvastatin: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Cyclosporine markedly raises simvastatin acid exposure, which greatly increases the risk of myopathy and rhabdomyolysis. Cases of severe muscle toxicity with renal failure have been described with statin and cyclosporine combinations.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cyclosporine and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Cyclosporine inhibits OATP1B1-mediated hepatic uptake and CYP3A4 metabolism of simvastatin, raising systemic statin concentrations.
क्या करें
Do not combine simvastatin with cyclosporine; choose a statin with a safer profile (such as low-dose pravastatin or fluvastatin, per labeling) and monitor for muscle symptoms and CK.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cyclosporine और Simvastatin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Simvastatin के अन्य इंटरैक्शन
- Atazanavir + Simvastatin निषिद्ध
- Clarithromycin + Simvastatin निषिद्ध
- Cobicistat + Simvastatin निषिद्ध
- Cyclosporin + Simvastatin निषिद्ध
- Danazol + Simvastatin निषिद्ध
- Darunavir + Simvastatin निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Cyclosporine with Simvastatin?
MediHelp rates the interaction as contraindicated. Cyclosporine and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine markedly raises simvastatin acid exposure, which greatly increases the risk of myopathy and rhabdomyolysis. Cases of severe muscle toxicity with renal failure have been described with statin and cyclosporine combinations.
How serious is the interaction between Cyclosporine and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine simvastatin with cyclosporine; choose a statin with a safer profile (such as low-dose pravastatin or fluvastatin, per labeling) and monitor for muscle symptoms and CK.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
