दवाओं की अंतःक्रिया
Clarithromycin + Simvastatin
गंभीरता: निषिद्ध
Clarithromycin and Simvastatin: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Clarithromycin substantially increases simvastatin acid exposure and raises the risk of myopathy and rhabdomyolysis, which may lead to acute kidney injury. The combination is contraindicated in simvastatin labeling. Older patients, those with renal impairment or on higher simvastatin doses are at greatest risk.
इस इंटरैक्शन का सरल भाषा में अर्थ
Clarithromycin and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Simvastatin belongs to Cardiovascular.
ऐसा क्यों होता है
Clarithromycin is a strong CYP3A4 inhibitor (and P-gp inhibitor), reducing the first-pass and systemic metabolism of simvastatin and its active acid.
क्या करें
Do not use together; suspend simvastatin for the duration of clarithromycin therapy, or use an alternative antibiotic such as azithromycin. For short courses, temporary interruption is usually preferred; pravastatin or rosuvastatin are options if statin continuation is essential.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Clarithromycin और Simvastatin की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
Simvastatin के अन्य इंटरैक्शन
- Atazanavir + Simvastatin निषिद्ध
- Cobicistat + Simvastatin निषिद्ध
- Cyclosporine + Simvastatin निषिद्ध
- Cyclosporin + Simvastatin निषिद्ध
- Danazol + Simvastatin निषिद्ध
- Darunavir + Simvastatin निषिद्ध
Clarithromycin के अन्य इंटरैक्शन
- Astemizole + Clarithromycin निषिद्ध
- Avanafil + Clarithromycin निषिद्ध
- Cisapride + Clarithromycin निषिद्ध
- Clarithromycin + Colchicine निषिद्ध
- Clarithromycin + Conivaptan निषिद्ध
- Clarithromycin + Dihydroergotamine निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Clarithromycin with Simvastatin?
MediHelp rates the interaction as contraindicated. Clarithromycin and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin substantially increases simvastatin acid exposure and raises the risk of myopathy and rhabdomyolysis, which may lead to acute kidney injury. The combination is contraindicated in simvastatin labeling. Older patients, those with renal impairment or on higher simvastatin doses are at greatest risk.
How serious is the interaction between Clarithromycin and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; suspend simvastatin for the duration of clarithromycin therapy, or use an alternative antibiotic such as azithromycin. For short courses, temporary interruption is usually preferred; pravastatin or rosuvastatin are options if statin continuation is essential.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Cobicistat, Cyclosporine. The full list is on the Simvastatin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
