दवाओं की अंतःक्रिया
Daunorubicin + Trastuzumab
गंभीरता: गंभीर
Daunorubicin and Trastuzumab: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Trastuzumab causes cardiac dysfunction, and anthracyclines such as daunorubicin cause cumulative dose-related cardiomyopathy. Used together or in close sequence, the risk of symptomatic heart failure and reduced ejection fraction is clearly higher than with either drug alone.
इस इंटरैक्शन का सरल भाषा में अर्थ
Daunorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Daunorubicin belongs to Oncology; Trastuzumab belongs to Oncology.
ऐसा क्यों होता है
Additive cardiotoxicity: anthracycline myocyte injury combined with impaired HER2-dependent cardiomyocyte survival signaling.
क्या करें
Avoid concurrent use where possible and keep a long interval between anthracycline and trastuzumab. Assess LVEF before and regularly during treatment, and stop trastuzumab if significant decline occurs.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Daunorubicin और Trastuzumab की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Daunorubicin के अन्य इंटरैक्शन
Trastuzumab के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Daunorubicin with Trastuzumab?
MediHelp rates the interaction as major. Daunorubicin and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab causes cardiac dysfunction, and anthracyclines such as daunorubicin cause cumulative dose-related cardiomyopathy. Used together or in close sequence, the risk of symptomatic heart failure and reduced ejection fraction is clearly higher than with either drug alone.
How serious is the interaction between Daunorubicin and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and keep a long interval between anthracycline and trastuzumab. Assess LVEF before and regularly during treatment, and stop trastuzumab if significant decline occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
