दवाओं की अंतःक्रिया
Doxorubicin liposomal + Trastuzumab
गंभीरता: गंभीर
Doxorubicin liposomal and Trastuzumab: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Trastuzumab can cause left ventricular dysfunction and heart failure, and the risk is greatest when it is given with or soon after anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin but still adds cardiac risk.
इस इंटरैक्शन का सरल भाषा में अर्थ
Doxorubicin liposomal and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
ऐसा क्यों होता है
Additive cardiotoxicity: anthracycline myocyte injury combined with impaired HER2-dependent cardiomyocyte repair from trastuzumab.
क्या करें
Avoid the combination if possible. If it is used, assess left ventricular ejection fraction before and at regular intervals during treatment, and stop trastuzumab for significant decline.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Doxorubicin liposomal और Trastuzumab की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Trastuzumab के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Doxorubicin liposomal with Trastuzumab?
MediHelp rates the interaction as major. Doxorubicin liposomal and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab can cause left ventricular dysfunction and heart failure, and the risk is greatest when it is given with or soon after anthracyclines. Liposomal doxorubicin is less cardiotoxic than conventional doxorubicin but still adds cardiac risk.
How serious is the interaction between Doxorubicin liposomal and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is used, assess left ventricular ejection fraction before and at regular intervals during treatment, and stop trastuzumab for significant decline.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin, Epirubicin. The full list is on the Trastuzumab page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
