दवाओं की अंतःक्रिया
Deferiprone + Pyrimethamine
गंभीरता: गंभीर
Deferiprone and Pyrimethamine: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Deferiprone can cause neutropenia and agranulocytosis, and pyrimethamine, as a folate antagonist, can cause bone marrow suppression. Combined use may increase the risk of severe hematologic toxicity.
इस इंटरैक्शन का सरल भाषा में अर्थ
Deferiprone and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
ऐसा क्यों होता है
Additive myelosuppression (pharmacodynamic); pyrimethamine inhibits dihydrofolate reductase.
क्या करें
Avoid the combination if an alternative exists. If it is necessary, monitor absolute neutrophil count and platelets more frequently, and interrupt deferiprone for neutropenia.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Deferiprone और Pyrimethamine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Pyrimethamine के अन्य इंटरैक्शन
Deferiprone के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Deferiprone with Pyrimethamine?
MediHelp rates the interaction as major. Deferiprone and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and pyrimethamine, as a folate antagonist, can cause bone marrow suppression. Combined use may increase the risk of severe hematologic toxicity.
How serious is the interaction between Deferiprone and Pyrimethamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor absolute neutrophil count and platelets more frequently, and interrupt deferiprone for neutropenia.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Eliglustat, Acalabrutinib, Brexpiprazole. The full list is on the Pyrimethamine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
