दवाओं की अंतःक्रिया
Folic acid + Pyrimethamine
गंभीरता: मध्यम
Folic acid and Pyrimethamine: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
इस इंटरैक्शन का सरल भाषा में अर्थ
Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
ऐसा क्यों होता है
Pharmacodynamic antagonism, as folic acid supplies the folate end-product whose synthesis pyrimethamine blocks.
क्या करें
Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Folic acid और Pyrimethamine की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Pyrimethamine के अन्य इंटरैक्शन
Folic acid के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Folic acid with Pyrimethamine?
MediHelp rates the interaction as moderate. Folic acid and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine inhibits parasitic dihydrofolate reductase, and supplemental folic acid can reduce its antiparasitic effect. For toxoplasmosis this may lead to treatment failure. Folinic acid is usually used instead to protect the marrow without blunting efficacy.
How serious is the interaction between Folic acid and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid folic acid supplementation during pyrimethamine treatment of toxoplasmosis and give folinic acid (leucovorin) to prevent haematological toxicity. Monitor blood counts.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
