दवाओं की अंतःक्रिया
Desipramine + Safinamide
गंभीरता: निषिद्ध
Desipramine and Safinamide: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
इस इंटरैक्शन का सरल भाषा में अर्थ
Desipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
ऐसा क्यों होता है
Additive serotonergic activity: reversible MAO-B inhibition (selectivity is lost at higher doses) plus monoamine reuptake inhibition
क्या करें
Do not combine; allow at least 14 days after stopping the safinamide before starting desipramine, and at least 14 days after stopping desipramine before starting the safinamide.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Desipramine और Safinamide की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Desipramine के अन्य इंटरैक्शन
- Desipramine + Disopyramide निषिद्ध
- Desipramine + Dofetilide निषिद्ध
- Desipramine + Ibutilide निषिद्ध
- Desipramine + Isocarboxazid निषिद्ध
- Desipramine + Methylene blue निषिद्ध
- Desipramine + Pentamidine निषिद्ध
Safinamide के अन्य इंटरैक्शन
- Amitriptyline + Safinamide निषिद्ध
- Amoxapine + Safinamide निषिद्ध
- Amphetamine polistirex + Safinamide निषिद्ध
- Clomipramine + Safinamide निषिद्ध
- Cyclobenzaprine + Safinamide निषिद्ध
- Desvenlafaxine + Safinamide निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Desipramine with Safinamide?
MediHelp rates the interaction as contraindicated. Desipramine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide inhibits monoamine oxidase and so reduces serotonin breakdown, while desipramine is a tricyclic antidepressant that blocks norepinephrine reuptake and, to a lesser degree, serotonin reuptake. Together this can precipitate serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability that may be fatal. Hypertensive reactions are also possible with tricyclic agents.
How serious is the interaction between Desipramine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping the safinamide before starting desipramine, and at least 14 days after stopping desipramine before starting the safinamide.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
