दवाओं की अंतःक्रिया
Elagolix + Ketoconazole
गंभीरता: गंभीर
Elagolix and Ketoconazole: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Strong CYP3A inhibition by ketoconazole increases elagolix exposure, raising the risk of dose-related effects such as bone mineral density loss and liver enzyme elevations. Risk is greater with longer duration of use.
इस इंटरैक्शन का सरल भाषा में अर्थ
Elagolix and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elagolix belongs to Musculoskeletal; Ketoconazole belongs to Anti Fungals.
ऐसा क्यों होता है
Ketoconazole inhibits CYP3A4-mediated metabolism of elagolix.
क्या करें
Avoid long-term use with the 200 mg twice-daily dose; if the combination is needed, limit elagolix to 150 mg once daily and restrict the inhibitor course to a maximum of 6 months.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Elagolix और Ketoconazole की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Ketoconazole के अन्य इंटरैक्शन
- Alfuzosin + Ketoconazole निषिद्ध
- Alprazolam + Ketoconazole निषिद्ध
- Avanafil + Ketoconazole निषिद्ध
- Conivaptan + Ketoconazole निषिद्ध
- Dihydroergotamine intranasal + Ketoconazole निषिद्ध
- Dihydroergotamine + Ketoconazole निषिद्ध
Elagolix के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Elagolix with Ketoconazole?
MediHelp rates the interaction as major. Elagolix and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A inhibition by ketoconazole increases elagolix exposure, raising the risk of dose-related effects such as bone mineral density loss and liver enzyme elevations. Risk is greater with longer duration of use.
How serious is the interaction between Elagolix and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use with the 200 mg twice-daily dose; if the combination is needed, limit elagolix to 150 mg once daily and restrict the inhibitor course to a maximum of 6 months.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
