दवाओं की अंतःक्रिया
Imipenem / cilastatin + Valproic acid
गंभीरता: निषिद्ध
Imipenem / cilastatin and Valproic acid: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Carbapenems rapidly and substantially lower serum valproate concentrations, often within a day, and can precipitate breakthrough seizures. The effect may persist for days after the carbapenem is stopped and is not reliably overcome by raising the valproate dose.
इस इंटरैक्शन का सरल भाषा में अर्थ
Imipenem / cilastatin and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
ऐसा क्यों होता है
Carbapenems inhibit acylpeptide hydrolase, blocking hydrolysis of valproate glucuronide back to valproate, and may also reduce its absorption or increase its distribution into red cells.
क्या करें
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant cover and monitor valproate levels and seizure activity.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Imipenem / cilastatin और Valproic acid की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Valproic acid के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Imipenem / cilastatin with Valproic acid?
MediHelp rates the interaction as contraindicated. Imipenem / cilastatin and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbapenems rapidly and substantially lower serum valproate concentrations, often within a day, and can precipitate breakthrough seizures. The effect may persist for days after the carbapenem is stopped and is not reliably overcome by raising the valproate dose.
How serious is the interaction between Imipenem / cilastatin and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is essential, add alternative anticonvulsant cover and monitor valproate levels and seizure activity.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Meropenem / vaborbactam. The full list is on the Valproic acid page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
