दवाओं की अंतःक्रिया
Cilastatin-imipenem + Valproic acid
गंभीरता: गंभीर
Cilastatin-imipenem and Valproic acid: major interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Carbapenems, including imipenem, rapidly and markedly lower serum valproate concentrations, which can lead to loss of seizure control. The effect begins within a day or two and may persist for some days after stopping the carbapenem.
इस इंटरैक्शन का सरल भाषा में अर्थ
Cilastatin-imipenem and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilastatin-imipenem belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
ऐसा क्यों होता है
Carbapenems inhibit hydrolysis of valproate glucuronide and may reduce its absorption and distribution, lowering valproate levels.
क्या करें
Avoid the combination and use a non-carbapenem antibiotic. Increasing the valproate dose is usually ineffective, so add or switch to another anticonvulsant if a carbapenem is unavoidable.
फार्मासिस्ट से क्या पूछें
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Cilastatin-imipenem और Valproic acid की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Cilastatin-imipenem के अन्य इंटरैक्शन
Valproic acid के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Cilastatin-imipenem with Valproic acid?
MediHelp rates the interaction as major. Cilastatin-imipenem and Valproic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbapenems, including imipenem, rapidly and markedly lower serum valproate concentrations, which can lead to loss of seizure control. The effect begins within a day or two and may persist for some days after stopping the carbapenem.
How serious is the interaction between Cilastatin-imipenem and Valproic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. Increasing the valproate dose is usually ineffective, so add or switch to another anticonvulsant if a carbapenem is unavoidable.
What other medicines interact with Cilastatin-imipenem?
MediHelp also lists interactions of Cilastatin-imipenem with, for example, Divalproex, Ganciclovir, Bcg intravesical live. The full list is on the Cilastatin-imipenem page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
