दवाओं की अंतःक्रिया
Irinotecan + Telotristat etiprate
गंभीरता: मध्यम
Irinotecan and Telotristat etiprate: moderate interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Irinotecan is converted to its active metabolite SN-38 by carboxylesterases, and telotristat's metabolite may inhibit CES2. This could reduce activation and efficacy, or alter toxicity, though clinical data are lacking.
इस इंटरैक्शन का सरल भाषा में अर्थ
Irinotecan and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
ऐसा क्यों होता है
Carboxylesterase 2 inhibition may reduce conversion of irinotecan to SN-38.
क्या करें
Monitor tumour response and for diarrhoea and neutropenia during co-administration.
फार्मासिस्ट से क्या पूछें
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Irinotecan और Telotristat etiprate की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 7 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Telotristat etiprate के अन्य इंटरैक्शन
Irinotecan के अन्य इंटरैक्शन
अक्सर पूछे जाने वाले प्रश्न
Can I take Irinotecan with Telotristat etiprate?
MediHelp rates the interaction as moderate. Irinotecan and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irinotecan is converted to its active metabolite SN-38 by carboxylesterases, and telotristat's metabolite may inhibit CES2. This could reduce activation and efficacy, or alter toxicity, though clinical data are lacking.
How serious is the interaction between Irinotecan and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumour response and for diarrhoea and neutropenia during co-administration.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
