दवाओं की अंतःक्रिया
Isocarboxazid + Nortriptyline
गंभीरता: निषिद्ध
Isocarboxazid and Nortriptyline: contraindicated interaction.
अंतिम अपडेट
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and nortriptyline is a tricyclic antidepressant that blocks noradrenaline and serotonin reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
इस इंटरैक्शन का सरल भाषा में अर्थ
Isocarboxazid and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
ऐसा क्यों होता है
Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)
क्या करें
Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting nortriptyline, and at least 14 days after stopping nortriptyline before starting isocarboxazid.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Isocarboxazid और Nortriptyline की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
Nortriptyline के अन्य इंटरैक्शन
- Disopyramide + Nortriptyline निषिद्ध
- Dofetilide + Nortriptyline निषिद्ध
- Dronedarone + Nortriptyline निषिद्ध
- Ibutilide + Nortriptyline निषिद्ध
- Methylene blue + Nortriptyline निषिद्ध
- Nortriptyline + Pentamidine निषिद्ध
Isocarboxazid के अन्य इंटरैक्शन
- 5-HTP + Isocarboxazid निषिद्ध
- Amitriptyline + Isocarboxazid निषिद्ध
- Amobarbital + Isocarboxazid निषिद्ध
- Amoxapine + Isocarboxazid निषिद्ध
- Apraclonidine + Isocarboxazid निषिद्ध
- Atomoxetine + Isocarboxazid निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Isocarboxazid with Nortriptyline?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Nortriptyline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and nortriptyline is a tricyclic antidepressant that blocks noradrenaline and serotonin reuptake. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.
How serious is the interaction between Isocarboxazid and Nortriptyline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting nortriptyline, and at least 14 days after stopping nortriptyline before starting isocarboxazid.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
