दवाओं की अंतःक्रिया
Ketoconazole + Ticagrelor
गंभीरता: निषिद्ध
Ketoconazole and Ticagrelor: contraindicated interaction.
अंतिम अपडेट स्रोत: US FDA label
केवल स्वास्थ्य पेशेवरों के लिए — मात्र संदर्भ हेतु। यह पृष्ठ संक्षिप्त सारांश है, चिकित्सकीय सलाह नहीं है और आधिकारिक लेबल या नैदानिक निर्णय का विकल्प नहीं है। दवा लिखने या देने से पहले हमेशा जाँच करें।
इस पृष्ठ की नैदानिक सामग्री केवल अंग्रेज़ी में उपलब्ध है।
सारांश
Ketoconazole substantially increases ticagrelor exposure, raising the risk of bleeding. Ticagrelor labeling lists strong CYP3A4 inhibitors as contraindicated or to be avoided. The risk is greatest in patients also on aspirin or anticoagulants.
इस इंटरैक्शन का सरल भाषा में अर्थ
Ketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Ticagrelor belongs to Cardiovascular.
ऐसा क्यों होता है
Ketoconazole is a strong CYP3A4 and P-glycoprotein inhibitor and blocks ticagrelor clearance, increasing levels of the parent drug.
क्या करें
Avoid the combination; use an alternative antifungal with less CYP3A4 inhibition, or another P2Y12 inhibitor such as prasugrel or clopidogrel where appropriate. If antifungal therapy cannot be changed, review the antiplatelet choice with cardiology.
फार्मासिस्ट से क्या पूछें
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ सदस्यों के लिए
पूरा पेज खोलें
Ketoconazole और Ticagrelor की पूरी प्रबंधन सलाह, अतिरिक्त नोट्स, साक्ष्य का विवरण और पूरे पर्चे का इंटरैक्शन चेकर खोलने के लिए खाता बनाएँ और Pro+ ट्रायल शुरू करें।
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
वेब पर Pro+ को 14 दिन मुफ़्त आज़माएँ। कार्ड की ज़रूरत नहीं।
संदर्भ
- Brilinta (ticagrelor) Prescribing Information - Drug Interactions — FDA Label
- Brilique (ticagrelor) Summary of Product Characteristics — EMA SmPC
Ticagrelor के अन्य इंटरैक्शन
- Itraconazole + Ticagrelor निषिद्ध
- Levoketoconazole + Ticagrelor निषिद्ध
- Abciximab + Ticagrelor गंभीर
- Abrocitinib + Ticagrelor गंभीर
- Acalabrutinib + Ticagrelor गंभीर
- Acetylsalicylic acid + Ticagrelor गंभीर
Ketoconazole के अन्य इंटरैक्शन
- Alfuzosin + Ketoconazole निषिद्ध
- Alprazolam + Ketoconazole निषिद्ध
- Avanafil + Ketoconazole निषिद्ध
- Conivaptan + Ketoconazole निषिद्ध
- Dihydroergotamine intranasal + Ketoconazole निषिद्ध
- Dihydroergotamine + Ketoconazole निषिद्ध
अक्सर पूछे जाने वाले प्रश्न
Can I take Ketoconazole with Ticagrelor?
MediHelp rates the interaction as contraindicated. Ketoconazole and Ticagrelor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole substantially increases ticagrelor exposure, raising the risk of bleeding. Ticagrelor labeling lists strong CYP3A4 inhibitors as contraindicated or to be avoided. The risk is greatest in patients also on aspirin or anticoagulants.
How serious is the interaction between Ketoconazole and Ticagrelor?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antifungal with less CYP3A4 inhibition, or another P2Y12 inhibitor such as prasugrel or clopidogrel where appropriate. If antifungal therapy cannot be changed, review the antiplatelet choice with cardiology.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Levoketoconazole, Abciximab. The full list is on the Ticagrelor page.
MediHelp ऐप में पूर्ण मोनोग्राफ़, खुराक और इंटरैक्शन चेकर
MediHelp ऐप में पूरा संदर्भ खोलें, कई दवाओं की अंतःक्रियाएँ जाँचें और खुराक टूल इस्तेमाल करें।
