Riferimento farmaci
Burosumab
Burosumab is a medicine in the class miscellaneous. It is used for hypophosphatemia.
- Classe del farmaco: Miscellaneous
- Indicato per: hypophosphatemia
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Miscellaneous
- Codice ATC
- M05BX05
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 10 mg/ml
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Burosumab-twza binds to and inhibits the biological activity of FGF23, restoring renal phosphate reabsorption and increasing serum 1,25 dihydroxy vitamin D.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Adult XLH: starting 1 mg/kg rounded to nearest 10 mg, maximum 90 mg, subcutaneously every four weeks; may increase to 0.5 mg/kg (max 90 mg) every 2 weeks, then 1 mg/kg (max 90 mg) every 2 weeks if needed.
Gravidanza e allattamento
- Gravidanza
- Unknown No human data. In monkeys there were no birth defects, but fetal loss and preterm birth at high exposure with high maternal phosphate. Monitor serum phosphate throughout pregnancy.
- Allattamento
- Unknown No data on milk levels or infant effects. As a large antibody, infant absorption is likely low. Weigh breastfeeding benefits against the mother's need.
Effetti indesiderati segnalati
- Pyrexia
- Injection site reaction
- Cough
- Vomiting
- Headache
- Tooth abscess
Controindicazioni
- Concomitant use with oral phosphate and/or active vitamin D analogs, due to risk of hyperphosphatemia.
- When serum phosphorus is within or above the normal range for age.
- Severe renal impairment or end stage renal disease.
Chi deve prestare attenzione
- Hypersensitivity reactions (rash, urticaria) reported; discontinue if serious.
- Hyperphosphatemia may increase nephrocalcinosis risk; dose interruption or reduction may be required.
- Hypercalcemia: monitor calcium and PTH in high-risk patients; do not administer in moderate to severe hypercalcemia until managed.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
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Domande frequenti
What is Burosumab used for?
Burosumab is a medicine in the class miscellaneous. It is used for Hypophosphatemia.
What side effects have been reported with Burosumab?
Pyrexia, Injection site reaction, Cough, Vomiting, Headache, Tooth abscess.
Can Burosumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. In monkeys there were no birth defects, but fetal loss and preterm birth at high exposure with high maternal phosphate. Monitor serum phosphate throughout pregnancy. Breastfeeding: Unknown. No data on milk levels or infant effects. As a large antibody, infant absorption is likely low. Weigh breastfeeding benefits against the mother's need.
What does Burosumab interact with?
MediHelp does not list a checked interaction for Burosumab yet. Always tell your pharmacist about every medicine you take.
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