Riferimento farmaci
Crizanlizumab
Crizanlizumab is a medicine in the class miscellaneous. It is used for sickle cell disease.
- Classe del farmaco: Miscellaneous
- Indicato per: sickle cell disease
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Miscellaneous
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 10 mg/ml
- Interazioni note
- 1 (Moderata: 1)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Humanized IgG2 kappa monoclonal antibody that binds P-selectin and blocks its interactions with ligands including PSGL-1; it can also dissociate preformed P-selectin/PSGL-1 complex.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Sickle cell disease (reduce frequency of vaso-occlusive crises): 5 mg/kg by intravenous infusion over 30 minutes at Week 0, Week 2, and every 4 weeks thereafter; may be given with or without hydroxyurea
Gravidanza e allattamento
- Gravidanza
- Unknown May cause fetal harm: in monkeys it increased fetal loss (abortions, stillbirths). Human data are insufficient. Sickle cell disease itself raises pregnancy risks. Use only if the benefit justifies the potential risk to the fetus.
- Allattamento
- Unknown No data on milk levels or infant effects. Human IgG passes into milk; effects of the small infant exposure are unknown. Weigh the benefits of breastfeeding against the mother's need for treatment.
Effetti indesiderati segnalati
- Headache
- Arthralgia
- Nausea
- Back pain
- Fatigue
- Abdominal pain
Chi deve prestare attenzione
- Infusion-related reactions (pain, nausea, vomiting, fatigue, dizziness, pruritus, diarrhea, pyrexia), some requiring hospitalization; mostly during first and second infusions. Interrupt or slow the infusion for mild/moderate reactions, discontinue for severe ones; consider premedication for later infusions.
- Infusion-related reactions can be indistinguishable from vaso-occlusive crisis events and may occur together.
- Use caution with corticosteroids in sickle cell disease unless clinically indicated; they may increase the risk of acute chest syndrome and fat embolism.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (1)
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Domande frequenti
What is Crizanlizumab used for?
Crizanlizumab is a medicine in the class miscellaneous. It is used for Sickle cell disease.
What side effects have been reported with Crizanlizumab?
Headache, Arthralgia, Nausea, Back pain, Fatigue, Abdominal pain.
Can Crizanlizumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. May cause fetal harm: in monkeys it increased fetal loss (abortions, stillbirths). Human data are insufficient. Sickle cell disease itself raises pregnancy risks. Use only if the benefit justifies the potential risk to the fetus. Breastfeeding: Unknown. No data on milk levels or infant effects. Human IgG passes into milk; effects of the small infant exposure are unknown. Weigh the benefits of breastfeeding against the mother's need for treatment.
What does Crizanlizumab interact with?
MediHelp lists 1 known interactions for Crizanlizumab. Moderate: 1. The most serious include Exagamglogene autotemcel.
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