Riferimento farmaci
Daraxonrasib
Daraxonrasib is a medicine in the class oncology. It is used for pancreatic cancer.
- Classe del farmaco: Oncology
- Indicato per: pancreatic cancer
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Oncology
- Forme farmaceutiche comuni
- compressa
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Inhibitor of the RAS GTPase family. It binds cyclophilin A, and the resulting complex binds active GTP-bound RAS, blocking downstream effector interactions and promoting GTP hydrolysis to inactive GDP-bound RAS.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Metastatic pancreatic adenocarcinoma (after at least one prior systemic therapy or not a candidate for multiagent therapy): 300 mg orally once daily at the same time each day, with or without food, until disease progression or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unsafe Can cause fetal harm: in mice it caused fetal death, growth changes and malformations at exposures 2.5 times the human dose; no human data. Avoid in pregnancy; check pregnancy status before starting and use effective contraception during treatment and for 1 week after the last dose.
- Allattamento
- Unsafe No data on milk levels or infant effects. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
Effetti indesiderati segnalati
- Rash
- Diarrhea
- Stomatitis
- Nausea
- Fatigue
- Vomiting
Chi deve prestare attenzione
- Dermatologic and soft tissue toxicity (rash, pruritus, paronychia, dry skin), which may be severe. Use prophylaxis before the first dose and limit sun exposure.
- Stomatitis and oral disorders, including mouth ulcers and oral mucositis. Monitor and treat with a steroid-containing mouthwash.
- Diarrhea: give antidiarrheal treatment as clinically indicated, and withhold, reduce or discontinue based on severity.
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- Renal and hepatic dose adjustments
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Domande frequenti
What is Daraxonrasib used for?
Daraxonrasib is a medicine in the class oncology. It is used for Pancreatic cancer.
What side effects have been reported with Daraxonrasib?
Rash, Diarrhea, Stomatitis, Nausea, Fatigue, Vomiting.
Can Daraxonrasib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: in mice it caused fetal death, growth changes and malformations at exposures 2.5 times the human dose; no human data. Avoid in pregnancy; check pregnancy status before starting and use effective contraception during treatment and for 1 week after the last dose. Breastfeeding: Unsafe. No data on milk levels or infant effects. Because of possible serious reactions in the infant, do not breastfeed during treatment and for 1 week after the last dose.
What does Daraxonrasib interact with?
MediHelp does not list a checked interaction for Daraxonrasib yet. Always tell your pharmacist about every medicine you take.
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