Riferimento farmaci
Diazoxide
Diazoxide is a medicine in the class miscellaneous. It is used for hypoglycemia.
- Classe del farmaco: Miscellaneous
- Indicato per: hypoglycemia
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Miscellaneous
- Forme farmaceutiche comuni
- sospensione orale
- Dosaggi comuni
- 50 mg/ml
- Interazioni note
- 40 (Maggiore: 10 · Moderata: 30)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Produces a dose-related rise in blood glucose, mainly by inhibiting insulin release from the pancreas, with an additional extrapancreatic effect.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hypoglycemia due to hyperinsulinism (adults and children): starting 3 mg/kg/day orally, divided into 3 equal doses every 8 hours or 2 equal doses every 12 hours; titrate to a maximum of 8 mg/kg/day; refractory hypoglycemia may need higher doses
Gravidanza e allattamento
- Gravidanza
- Unsafe Case reports are too few to assess birth-defect risk. It crosses the placenta: use before delivery has caused high blood sugar, hair loss and excess body hair in newborns, and labels warn of jaundice and low platelets. Use only if the mother's benefit outweighs the risk.
- Allattamento
- Unknown Present in human milk; no data on infant effects or milk supply. US labels: weigh breastfeeding against the mother's need (older label: choose one). If used, monitor the infant's blood glucose, especially in the newborn period.
Effetti indesiderati segnalati
- Sodium and fluid retention
- Hirsutism (lanugo type)
- Hyperglycemia or glycosuria
- Anorexia, nausea, vomiting, abdominal pain, diarrhea
- Tachycardia and palpitations
- Increased serum uric acid
Controindicazioni
- Functional hypoglycemia
- Hypersensitivity to diazoxide, its excipients, or other thiazides
Chi deve prestare attenzione
- Fluid retention from antidiuretic effect may precipitate congestive heart failure in patients with compromised cardiac reserve.
- Ketoacidosis and nonketotic hyperosmolar coma reported, usually during intercurrent illness; long half-life requires prolonged surveillance; patients should monitor urine glucose and ketones.
- Pulmonary hypertension reported in neonates and infants; monitor and discontinue if suspected.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (40)
- Alogliptin-metformin + Diazoxide Major
- Canagliflozin-metformin + Diazoxide Major
- Diazoxide + Empagliflozin-metformin Major
- Diazoxide + Glipizide-metformin Major
- Diazoxide + Glyburide-metformin Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-liraglutide Major
- Diazoxide + Linagliptin-metformin Major
- Diazoxide + Metformin-pioglitazone Major
- Diazoxide + Metformin-sitagliptin Major
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- Patient counselling points
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Domande frequenti
What is Diazoxide used for?
Diazoxide is a medicine in the class miscellaneous. It is used for Hypoglycemia.
What side effects have been reported with Diazoxide?
Sodium and fluid retention, Hirsutism (lanugo type), Hyperglycemia or glycosuria, Anorexia, nausea, vomiting, abdominal pain, diarrhea, Tachycardia and palpitations, Increased serum uric acid.
Can Diazoxide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Case reports are too few to assess birth-defect risk. It crosses the placenta: use before delivery has caused high blood sugar, hair loss and excess body hair in newborns, and labels warn of jaundice and low platelets. Use only if the mother's benefit outweighs the risk. Breastfeeding: Unknown. Present in human milk; no data on infant effects or milk supply. US labels: weigh breastfeeding against the mother's need (older label: choose one). If used, monitor the infant's blood glucose, especially in the newborn period.
What does Diazoxide interact with?
MediHelp lists 40 known interactions for Diazoxide. Major: 10 · Moderate: 30. The most serious include Alogliptin-metformin, Canagliflozin-metformin, Empagliflozin-metformin.
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