Riferimento farmaci
Fostemsavir
Fostemsavir is a medicine in the class anti virals. It is used for hiv.
- Classe del farmaco: Anti Virals
- Indicato per: hiv
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Anti Virals
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 600 mg
- Interazioni note
- 157 (Controindicata: 6 · Maggiore: 5 · Moderata: 114 · Minore: 32)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
HIV-1 gp120-directed attachment inhibitor; HIV-1 antiretroviral agent. Fostemsavir is a prodrug of temsavir, the active moiety.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 (with other antiretrovirals): 600 mg tablet orally twice daily with or without food
Gravidanza e allattamento
- Gravidanza
- Unknown Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control.
- Allattamento
- Unknown Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
Effetti indesiderati segnalati
- Nausea
- Diarrhea
- Headache
- Abdominal pain
- Dyspepsia
- Fatigue
Controindicazioni
- Previous hypersensitivity to fostemsavir or any component of the formulation.
- Coadministration with strong CYP3A inducers (e.g., enzalutamide, carbamazepine, phenytoin, rifampin, mitotane, St John's wort) because of loss of virologic response.
Chi deve prestare attenzione
- Immune reconstitution syndrome, including inflammatory responses to opportunistic infections and autoimmune disorders, has been reported.
- QTc prolongation seen at higher than recommended doses; use caution with history of QT prolongation, cardiac disease, or drugs with Torsade de Pointes risk.
- Hepatic transaminase elevations in HBV/HCV co-infection, including hepatitis B reactivation; monitor liver chemistries.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (157)
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Efavirenz + Fostemsavir Major
- Fostemsavir + Lorlatinib Major
- Fostemsavir + Pimozide Major
- Fostemsavir + Sofosbuvir-velpatasvir-voxilaprevir Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
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- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Fostemsavir used for?
Fostemsavir is a medicine in the class anti virals. It is used for HIV.
What side effects have been reported with Fostemsavir?
Nausea, Diarrhea, Headache, Abdominal pain, Dyspepsia, Fatigue.
Can Fostemsavir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Insufficient human data to assess risk; no adverse developmental effects in rats and rabbits at clinically relevant exposures. Pregnancy registry exists. Used in heavily treated HIV when other options fail; continue if needed for viral control. Breastfeeding: Unknown. Not known whether it is in human milk; it is in rat milk. Risks include HIV transmission, viral resistance and infant side effects. US guidance supports breastfeeding only with sustained viral suppression after counselling; otherwise avoid.
What does Fostemsavir interact with?
MediHelp lists 157 known interactions for Fostemsavir. Contraindicated: 6 · Major: 5 · Moderate: 114 · Minor: 32. The most serious include Apalutamide, Carbamazepine, Enzalutamide.
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