Riferimento farmaci
Gefitinib
Gefitinib is a medicine in the class oncology. It is used for non-small cell lung cancer.
- Classe del farmaco: Oncology
- Indicato per: non-small cell lung cancer
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Oncology
- Codice ATC
- L01XE02
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 250 mg
- Interazioni note
- 39 (Maggiore: 10 · Moderata: 27 · Minore: 2)
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Gefitinib reversibly inhibits the kinase activity of wild-type and certain activating mutations of EGFR, preventing autophosphorylation and blocking downstream signaling and EGFR-dependent proliferation. It binds exon 19 deletion and L858R mutant EGFR with higher affinity than wild-type.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
First-line metastatic NSCLC with EGFR exon 19 deletions or exon 21 L858R mutations: 250 mg orally once daily with or without food until disease progression or unacceptable toxicity
Gravidanza e allattamento
- Gravidanza
- Unsafe Can cause fetal harm when given to a pregnant woman; animal studies showed fetotoxicity and neonatal death at doses below the recommended human dose.
- Allattamento
- Unsafe It is not known whether excreted in human milk; present in rat milk. Advise women to discontinue breast-feeding during treatment.
Effetti indesiderati segnalati
- Skin reactions
- Diarrhea
- Nail disorders
- Increased ALT
- Increased AST
- Conjunctivitis, blepharitis and dry eye
Controindicazioni
- None.
Chi deve prestare attenzione
- Interstitial lung disease occurred in 1.3% of patients, with fatal cases. Withhold for worsening respiratory symptoms and discontinue if confirmed.
- Hepatotoxicity: obtain periodic liver function testing; withhold for worsening liver function; discontinue for severe hepatic impairment.
- Gastrointestinal perforation occurred in 0.1% of patients; discontinue permanently.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (39)
- Apalutamide + Gefitinib Major
- Carbamazepine + Gefitinib Major
- Dexlansoprazole + Gefitinib Major
- Esomeprazole + Gefitinib Major
- Gefitinib + Lansoprazole Major
- Gefitinib + Omeprazole Major
- Gefitinib + Pantoprazole Major
- Gefitinib + Phenytoin Major
- Gefitinib + Rabeprazole Major
- Gefitinib + Rifampicin Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Gefitinib used for?
Gefitinib is a medicine in the class oncology. It is used for Non-small cell lung cancer.
What side effects have been reported with Gefitinib?
Skin reactions, Diarrhea, Nail disorders, Increased ALT, Increased AST, Conjunctivitis, blepharitis and dry eye.
Can Gefitinib be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm when given to a pregnant woman; animal studies showed fetotoxicity and neonatal death at doses below the recommended human dose. Breastfeeding: Unsafe. It is not known whether excreted in human milk; present in rat milk. Advise women to discontinue breast-feeding during treatment.
What does Gefitinib interact with?
MediHelp lists 39 known interactions for Gefitinib. Major: 10 · Moderate: 27 · Minor: 2. The most serious include Apalutamide, Carbamazepine, Dexlansoprazole.
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