Riferimento farmaci
Lonapegsomatropin
Lonapegsomatropin is a medicine in the class endocrine. It is used for growth failure.
- Classe del farmaco: Endocrine
- Indicato per: growth failure
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Endocrine
- Codice ATC
- H01AC09
- Forme farmaceutiche comuni
- iniezione
- Interazioni note
- 99 (Moderata: 65 · Minore: 34)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Pegylated human growth hormone (somatropin) that binds the GH receptor on target cells, causing intracellular signalling. It has direct tissue and metabolic effects and indirect effects mediated by IGF-1, and stimulates skeletal growth in pediatric GHD through effects on the epiphyseal growth plates.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Adult GHD, age 30 to 60 years with no oral estrogen: start 1.4 mg subcutaneously once weekly; increase monthly based on clinical response and/or IGF-1; maximum 6.3 mg once weekly
Gravidanza e allattamento
- Gravidanza
- Unknown No data for lonapegsomatropin in pregnancy; decades of published data for somatropin, its active part, show no drug-related risk of birth defects or miscarriage, and rats showed no harm. Use in pregnancy only if needed.
- Allattamento
- Safe No milk data. A large protein expected to pass into milk only slightly; somatropin does not raise normal milk growth hormone levels and has no reported infant effects. LactMed: no special precautions are required.
Effetti indesiderati segnalati
- Viral infection
- Pyrexia
- Cough
- Nausea and vomiting
- Peripheral edema (adults)
Controindicazioni
- Acute critical illness after open heart surgery, abdominal surgery, multiple accidental trauma, or acute respiratory failure
- Hypersensitivity to somatropin or any excipient
- Pediatric patients with closed epiphyses
Chi deve prestare attenzione
- Severe hypersensitivity including anaphylaxis and angioedema may occur
- Increased risk of neoplasms: monitor for progression or recurrence; second neoplasms in childhood cancer survivors
- Glucose intolerance and diabetes may be unmasked; monitor glucose
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (99)
- Alogliptin + Lonapegsomatropin Moderate
- Alogliptin-metformin + Lonapegsomatropin Moderate
- Alogliptin-pioglitazone + Lonapegsomatropin Moderate
- Bazedoxifene-conjugated estrogens + Lonapegsomatropin Moderate
- Canagliflozin + Lonapegsomatropin Moderate
- Chlorpropamide + Lonapegsomatropin Moderate
- Cyclosporin + Lonapegsomatropin Moderate
- Dapagliflozin + Lonapegsomatropin Moderate
- Dapagliflozin-metformin + Lonapegsomatropin Moderate
- Desogestrel-ethinyl estradiol + Lonapegsomatropin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Lonapegsomatropin used for?
Lonapegsomatropin is a medicine in the class endocrine. It is used for Growth failure, Growth hormone deficiency.
What side effects have been reported with Lonapegsomatropin?
Viral infection, Pyrexia, Cough, Nausea and vomiting, Peripheral edema (adults).
Can Lonapegsomatropin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No data for lonapegsomatropin in pregnancy; decades of published data for somatropin, its active part, show no drug-related risk of birth defects or miscarriage, and rats showed no harm. Use in pregnancy only if needed. Breastfeeding: Safe. No milk data. A large protein expected to pass into milk only slightly; somatropin does not raise normal milk growth hormone levels and has no reported infant effects. LactMed: no special precautions are required.
What does Lonapegsomatropin interact with?
MediHelp lists 99 known interactions for Lonapegsomatropin. Moderate: 65 · Minor: 34. The most serious include Alogliptin, Alogliptin-metformin, Alogliptin-pioglitazone.
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