Riferimento farmaci
Lubiprostone
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for constipation.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: constipation
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Gastrointestinal Tract
- Forme farmaceutiche comuni
- capsula
- Dosaggi comuni
- 24 mcg, 8 mcg
- Interazioni note
- 3 (Moderata: 2 · Minore: 1)
- Nomi commerciali
- 12
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Locally acting chloride channel activator; increases intestinal fluid secretion and intestinal motility; acts locally at apical portion of intestine.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Irritable Bowel Syndrome With Constipation: 8 mcg PO BID
Gravidanza e allattamento
- Gravidanza
- Unknown Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices.
- Allattamento
- Safe No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
Effetti indesiderati segnalati
- Headache
- Diarrhea
- Nausea
Controindicazioni
- Hypersensitivity
- Mechanical GI obstruction
Chi deve prestare attenzione
- Syncope and hypotension reported, some of which required hospitalization; most cases occurred in patients taking 24 mcg twice daily and some occurred within hours.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (3)
- Linaclotide + Lubiprostone Moderate
- Lubiprostone + Mosapride Moderate
- Deflazacort + Lubiprostone Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Domande frequenti
What is Lubiprostone used for?
Lubiprostone is a medicine in the class gastrointestinal tract. It is used for Constipation, Irritable bowel syndrome.
What side effects have been reported with Lubiprostone?
Headache, Diarrhea, Nausea.
Can Lubiprostone be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited human data. Little drug reaches the blood (one metabolite is measurable). No birth defects in rats or rabbits; fetal loss in guinea pigs was probably due to maternal toxicity. Use only if the benefit justifies the risk; osmotic laxatives or fibre are usual first choices. Breastfeeding: Safe. No human milk data; neither lubiprostone nor its active metabolite was found in rat milk, so little is expected in human milk. LactMed: not expected to harm the infant. If used, watch the infant for diarrhoea.
What does Lubiprostone interact with?
MediHelp lists 3 known interactions for Lubiprostone. Moderate: 2 · Minor: 1. The most serious include Linaclotide, Mosapride, Deflazacort.
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