Riferimento farmaci
Methyldopa
Methyldopa is a medicine in the class cardiovascular. It is used for hypertension.
- Classe del farmaco: Cardiovascular
- Indicato per: hypertension
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In breve
- Classe del farmaco
- Cardiovascular
- Forme farmaceutiche comuni
- compressa
- Dosaggi comuni
- 250 mg, 500 mg
- Interazioni note
- 92 (Controindicata: 1 · Maggiore: 5 · Moderata: 82 · Minore: 4)
- Nomi commerciali
- 15
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Methyldopa may lower blood pressure by stimulating central inhibitory alpha-adrenergic receptors, false neurotransmission, and/or reduction of plasma renin activity.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hypertension (Initial): 250 mg PO q8-12hr for 2 days, increase q2Days PRN
Gravidanza e allattamento
- Gravidanza
- Safe Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine.
- Allattamento
- Safe Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
Effetti indesiderati segnalati
- Dizziness
- Bradycardia
- Angina
- Orthostatic hypotension
- Depression
- Lethargy
Controindicazioni
- Active liver disease, liver disorders associated with previous methyldopa treatment
- Hypersensitivity to methyldopa or other ingredients (eg, sulfites)
- Pheochromocytoma
Chi deve prestare attenzione
- May impair ability to perform hazardous tasks
- Interferes with some lab tests
- IM/SC NOT recommended due to erratic absorption
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (92)
- Methyldopa + Tranylcypromine Contraindicated
- Iobenguane i + Methyldopa Major
- Lofexidine + Methyldopa Major
- Methyldopa + Pexidartinib Major
- Methyldopa + Pretomanid Major
- Methyldopa + Thioridazine Major
- Adrenaline-articaine + Methyldopa Moderate
- Apomorphine + Methyldopa Moderate
- Aripiprazole + Methyldopa Moderate
- Benperidol + Methyldopa Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Altri farmaci della stessa classe
Domande frequenti
What is Methyldopa used for?
Methyldopa is a medicine in the class cardiovascular. It is used for Hypertension.
What side effects have been reported with Methyldopa?
Dizziness, Bradycardia, Angina, Orthostatic hypotension, Depression, Lethargy.
Can Methyldopa be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Decades of use in all trimesters without fetal harm; treated hypertensive pregnancies had better outcomes. Starting at 16 to 20 weeks was linked to a slightly smaller head size, with no effects at follow-up. An option for high blood pressure in pregnancy; NICE prefers labetalol, then nifedipine. Breastfeeding: Safe. Passes into milk in small amounts that are not expected to affect the infant; LactMed: no special precautions. US label: use with caution. NICE advises stopping methyldopa within 2 days after the birth and changing to another antihypertensive.
What does Methyldopa interact with?
MediHelp lists 92 known interactions for Methyldopa. Contraindicated: 1 · Major: 5 · Moderate: 82 · Minor: 4. The most serious include Tranylcypromine, Iobenguane i, Lofexidine.
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