Riferimento farmaci
Metreleptin
Metreleptin is a medicine in the class endocrine.
- Classe del farmaco: Endocrine
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Endocrine
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 11.3 mg/2.2 ml
- Interazioni note
- 23 (Maggiore: 4 · Moderata: 19)
- Nomi commerciali
- 2
- Paesi e mercati
- 2
Come agisce
Leptin analog that binds to and activates the human leptin receptor (ObR), a Class I cytokine receptor that signals through the JAK/STAT pathway, replacing deficient leptin in generalized lipodystrophy.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Generalized lipodystrophy, males greater than 40 kg: start 2.5 mg subcutaneously once daily; adjust by 1.25 mg to 2.5 mg; maximum 10 mg/day
Gravidanza e allattamento
- Gravidanza
- Unknown Pregnancy reports are too few to show a risk. In mice, prolonged labour, maternal deaths at birth and lower pup survival occurred from about the maximum human dose. If used in pregnancy, mix with preservative-free water (the bacteriostatic diluent has benzyl alcohol).
- Allattamento
- Unknown No data on metreleptin in milk; natural leptin is a normal milk component. It is a protein, so little is expected to be absorbed by the infant. No LactMed record. US label: weigh breastfeeding against the mother's need.
Effetti indesiderati segnalati
- Headache
- Hypoglycemia
- Decreased weight
- Abdominal pain
- Arthralgia
- Dizziness
Avvertenze in evidenza
- Neutralizing anti-metreleptin antibodies have been identified; they could inhibit endogenous leptin action and/or cause loss of efficacy. Severe infection and/or worsening metabolic control have been reported. Test for neutralizing antibodies in patients with severe infections or suspected loss of efficacy.
Controindicazioni
- General obesity not associated with congenital leptin deficiency.
- Prior severe hypersensitivity reactions to metreleptin or any product component.
Chi deve prestare attenzione
- Neutralizing antibodies may inhibit endogenous leptin and cause loss of efficacy; test if severe infections or loss of efficacy occur.
- T-cell lymphoma: consider benefits and risks in patients with acquired generalized lipodystrophy or significant hematologic abnormalities.
- Hypoglycemia with concomitant insulin or insulin secretagogues; monitor blood glucose.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (23)
- Insulin aspart + Metreleptin Major
- Insulin glargine + Metreleptin Major
- Insulin glargine-lixisenatide + Metreleptin Major
- Insulin lispro + Metreleptin Major
- Chlorpropamide + Metreleptin Moderate
- Cyclosporin + Metreleptin Moderate
- Gliclazide + Metreleptin Moderate
- Glimepiride + Metreleptin Moderate
- Glimepiride-pioglitazone + Metreleptin Moderate
- Glipizide + Metreleptin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Domande frequenti
What is Metreleptin used for?
Metreleptin is a medicine in the class endocrine.
What side effects have been reported with Metreleptin?
Headache, Hypoglycemia, Decreased weight, Abdominal pain, Arthralgia, Dizziness. Serious warning: Neutralizing anti-metreleptin antibodies have been identified; they could inhibit endogenous leptin action and/or cause loss of efficacy.
Can Metreleptin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Pregnancy reports are too few to show a risk. In mice, prolonged labour, maternal deaths at birth and lower pup survival occurred from about the maximum human dose. If used in pregnancy, mix with preservative-free water (the bacteriostatic diluent has benzyl alcohol). Breastfeeding: Unknown. No data on metreleptin in milk; natural leptin is a normal milk component. It is a protein, so little is expected to be absorbed by the infant. No LactMed record. US label: weigh breastfeeding against the mother's need.
What does Metreleptin interact with?
MediHelp lists 23 known interactions for Metreleptin. Major: 4 · Moderate: 19. The most serious include Insulin aspart, Insulin glargine, Insulin glargine-lixisenatide.
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