Riferimento farmaci
Oritavancin
Oritavancin is a medicine in the class anti bacterial. It is used for skin infections.
- Classe del farmaco: Anti Bacterial
- Indicato per: skin infections
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Anti Bacterial
- Codice ATC
- J01XA05
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 400 mg, 1200 mg/40 ml
- Interazioni note
- 12 (Controindicata: 1 · Moderata: 1 · Minore: 10)
- Nomi commerciali
- 3
- Paesi e mercati
- 2
Per cosa si usa
Come agisce
Oritavancin is a lipoglycopeptide antibacterial drug; the label gives no further mechanism detail.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
ABSSSI (adults 18 years and older): 1,200 mg as a single dose by intravenous infusion over 1 hour.
Gravidanza e allattamento
- Gravidanza
- Unknown No human data; no effects on embryo-fetal development or survival in rats or rabbits at doses about 25% of the single clinical dose. Weigh the need for this single-dose antibiotic against the unknown risk.
- Allattamento
- Unknown No human milk data; it passes into rat milk. LactMed: poorly absorbed by mouth, so unlikely to reach the infant's blood; watch for diarrhoea or thrush. With no published experience, an alternative may be preferred, especially with a newborn or preterm infant.
Effetti indesiderati segnalati
- Headache
- Nausea
- Vomiting
- Limb and subcutaneous abscesses
- Diarrhea
Controindicazioni
- Intravenous unfractionated heparin is contraindicated for 120 hours (5 days) after administration because aPTT may remain falsely elevated.
- Known hypersensitivity to oritavancin products.
Chi deve prestare attenzione
- Coagulation test interference: aPTT prolonged up to 120 hours, PT/INR up to 12 hours, ACT up to 24 hours; consider a chromogenic Factor Xa assay or an alternative anticoagulant not requiring aPTT.
- Serious hypersensitivity including anaphylaxis; discontinue infusion if it occurs and monitor patients with glycopeptide allergy.
- Infusion related reactions; stopping or slowing the infusion may stop them.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (12)
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Cyclosporin + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Flecainide + Oritavancin Minor
- Oritavancin + Phenytoin Minor
- Oritavancin + Quinidine Minor
- Oritavancin + Quinine Minor
- Oritavancin + Sirolimus Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Domande frequenti
What is Oritavancin used for?
Oritavancin is a medicine in the class anti bacterial. It is used for Skin infections.
What side effects have been reported with Oritavancin?
Headache, Nausea, Vomiting, Limb and subcutaneous abscesses, Diarrhea.
Can Oritavancin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data; no effects on embryo-fetal development or survival in rats or rabbits at doses about 25% of the single clinical dose. Weigh the need for this single-dose antibiotic against the unknown risk. Breastfeeding: Unknown. No human milk data; it passes into rat milk. LactMed: poorly absorbed by mouth, so unlikely to reach the infant's blood; watch for diarrhoea or thrush. With no published experience, an alternative may be preferred, especially with a newborn or preterm infant.
What does Oritavancin interact with?
MediHelp lists 12 known interactions for Oritavancin. Contraindicated: 1 · Moderate: 1 · Minor: 10. The most serious include Heparin, Warfarin, Carbamazepine.
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