Riferimento farmaci
Ornithine aspartate
Ornithine aspartate is a medicine in the class gastrointestinal tract. It is used for hepatic encephalopathy.
- Classe del farmaco: Gastrointestinal Tract
- Indicato per: hepatic encephalopathy
Ultimo aggiornamento
Per operatori sanitari — solo a scopo di riferimento. Questa pagina è una sintesi breve, non è un parere medico e non sostituisce il RCP ufficiale né il giudizio clinico. Verificare sempre prima di prescrivere o dispensare.
Il contenuto clinico di questa pagina è disponibile solo in inglese.
In breve
- Classe del farmaco
- Gastrointestinal Tract
Per cosa si usa
Come agisce
L-ornithine L-aspartate supplies two amino acids that lower blood ammonia. Ornithine activates the hepatic urea cycle (carbamoyl phosphate synthetase) and is a substrate for it, increasing conversion of ammonia to urea in periportal hepatocytes.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Hepatic encephalopathy (latent or manifest), oral granules: 3 to 6 g (1 to 2 sachets of 3 g) up to three times daily. Usual maximum is 18 g/day.
Gravidanza e allattamento
- Gravidanza
- Unknown No adequate human data. Labels (e.g. Hepa-Merz) advise avoiding it in pregnancy unless clearly necessary. Ornithine and aspartate are natural amino acids, but high doses used for liver disease have not been studied in pregnancy.
- Allattamento
- Unknown Not known if it passes into milk; no LactMed or e-lactancia record. Labels: avoid breastfeeding during treatment unless clearly necessary. Both components are natural amino acids, but high-dose effects on the infant are unstudied; avoid if possible or watch the infant.
Effetti indesiderati segnalati
- Nausea
- Vomiting
- Abdominal pain
- Flatulence
- Diarrhoea
- Limb pain
Controindicazioni
- Hypersensitivity to ornithine aspartate or to any of the excipients.
- Severe renal insufficiency (serum creatinine above 3 mg/100 mL).
Chi deve prestare attenzione
- With high doses, monitor serum and urine urea levels.
- Do not exceed an IV infusion rate of 5 g per hour; faster infusion increases nausea and vomiting.
- Hepatic encephalopathy may impair the ability to drive and use machines; take this into account during treatment.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Per gli utenti Pro+
Sblocca la pagina completa
Crei un account e avvii una prova di Pro+ per aprire la monografia completa di Ornithine aspartate: dosi, gravidanza e allattamento, effetti indesiderati, avvertenze e tutte le interazioni.
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
Provi Pro+ gratis per 14 giorni sul web. Nessuna carta.
Domande frequenti
What is Ornithine aspartate used for?
Ornithine aspartate is a medicine in the class gastrointestinal tract. It is used for Hepatic encephalopathy.
What side effects have been reported with Ornithine aspartate?
Nausea, Vomiting, Abdominal pain, Flatulence, Diarrhoea, Limb pain.
Can Ornithine aspartate be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No adequate human data. Labels (e.g. Hepa-Merz) advise avoiding it in pregnancy unless clearly necessary. Ornithine and aspartate are natural amino acids, but high doses used for liver disease have not been studied in pregnancy. Breastfeeding: Unknown. Not known if it passes into milk; no LactMed or e-lactancia record. Labels: avoid breastfeeding during treatment unless clearly necessary. Both components are natural amino acids, but high-dose effects on the infant are unstudied; avoid if possible or watch the infant.
What does Ornithine aspartate interact with?
MediHelp does not list a checked interaction for Ornithine aspartate yet. Always tell your pharmacist about every medicine you take.
Monografie complete, posologie e verifica delle interazioni nell'app MediHelp
Apra il riferimento completo, verifichi le interazioni tra più farmaci e usi gli strumenti di posologia nell'app MediHelp.
