Riferimento farmaci
Pyrilamine
Pyrilamine is a medicine in the class respiratory. It is used for allergic rhinitis.
- Classe del farmaco: Respiratory
- Indicato per: allergic rhinitis
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Respiratory
- Forme farmaceutiche comuni
- soluzione
- Dosaggi comuni
- 12.5 mg/15 ml
- Interazioni note
- 8 (Moderata: 2 · Minore: 6)
- Nomi commerciali
- 1
- Paesi e mercati
- 1
Per cosa si usa
Come agisce
Pyrilamine (mepyramine) is a first-generation ethylenediamine-class antihistamine that acts as an inverse agonist (competitive antagonist) at histamine H1 receptors. It blocks histamine-mediated vasodilation, increased capillary permeability and sensory nerve stimulation, which reduces sneezing, rhinorrhoea and itching.
Gravidanza e allattamento
- Gravidanza
- Unknown An older sedating antihistamine (mepyramine), often in cold or period-pain combinations. Human data are limited, with no clear link to birth defects. Loratadine, cetirizine or chlorphenamine are preferred; avoid decongestant combinations early in pregnancy.
- Allattamento
- Safe Small, occasional doses are not expected to harm the infant (LactMed: probably acceptable). Larger or prolonged doses may sedate the infant or lower milk supply, especially with a decongestant such as pseudoephedrine or before lactation is established. Non-sedating antihistamines are preferred.
Effetti indesiderati segnalati
- Marked drowsiness
- Excitability, especially in children
Chi deve prestare attenzione
- Ask a doctor before use if the child has a breathing problem such as emphysema or chronic bronchitis.
- Ask a doctor before use if the child has glaucoma.
- Marked drowsiness may occur; excitability may occur, especially in children.
Informare il farmacista o il medico di gravidanza o allattamento, malattie renali o epatiche, allergie e di ogni altro farmaco o integratore assunto.
Interazioni principali (8)
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
- Cariprazine + Pyrilamine Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- How to give it
- Patient counselling points
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Altri farmaci della stessa classe
Domande frequenti
What is Pyrilamine used for?
Pyrilamine is a medicine in the class respiratory. It is used for Allergic rhinitis, Hay fever.
What side effects have been reported with Pyrilamine?
Marked drowsiness, Excitability, especially in children.
Can Pyrilamine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. An older sedating antihistamine (mepyramine), often in cold or period-pain combinations. Human data are limited, with no clear link to birth defects. Loratadine, cetirizine or chlorphenamine are preferred; avoid decongestant combinations early in pregnancy. Breastfeeding: Safe. Small, occasional doses are not expected to harm the infant (LactMed: probably acceptable). Larger or prolonged doses may sedate the infant or lower milk supply, especially with a decongestant such as pseudoephedrine or before lactation is established. Non-sedating antihistamines are preferred.
What does Pyrilamine interact with?
MediHelp lists 8 known interactions for Pyrilamine. Moderate: 2 · Minor: 6. The most serious include Fentanyl, Levetiracetam, Amisulpride.
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