Riferimento farmaci
Sodium valproate
Sodium valproate is a medicine in the class central nervous system. It is used for epilepsy.
- Classe del farmaco: Central Nervous System
- Indicato per: epilepsy
Ultimo aggiornamento
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In breve
- Classe del farmaco
- Central Nervous System
- Noto anche come
- Valproate, Valproic acid
- Forme farmaceutiche comuni
- compressa, sciroppo, soluzione, capsula, gocce
- Dosaggi comuni
- 200 mg, 500 mg, 200 mg/ml
- Interazioni note
- 9 (Maggiore: 5 · Moderata: 4)
- Nomi commerciali
- 39
- Paesi e mercati
- 4
Per cosa si usa
Come agisce
Sodium valproate has a broad spectrum of anticonvulsant activity, but is structurally unrelated to conventional antiepileptic drugs. Its proposed mode of action is mediated through effects on the function of brain gamma-aminobutyric acid (GABA).
Dose abituale nell'adulto (sintesi del foglio illustrativo)
400-800mg depending on body weight (up to 10mg/kg) followed by continuous or repeated infusion up to a maximum of 2500mg/day.
Gravidanza e allattamento
- Gravidanza
- Unsafe Major birth-defect risk (about 1 in 10, incl. neural tube defects) and neurodevelopmental problems in up to 30-40% of exposed children. Contraindicated unless no alternative for epilepsy; never for migraine or (EU) bipolar. Specialist review; pregnancy prevention programme.
- Allattamento
- Safe Low levels in milk; usually acceptable. Watch the infant for jaundice, unusual bruising or bleeding; rare cases of low platelets reported.
Effetti indesiderati segnalati
- Vomiting
- Nausea
- Liver injury
- Stomatitis
- Pancreatitis
Chi deve prestare attenzione
- Pancreatitis, which may be severe and result in fatalities, has been very rarely reported. Patients experiencing nausea, vomiting or acute abdominal pain.
- Patients are advised not to stop valproate medication and to immediately contact a specialist in case of planned or suspected pregnancy.
- Suicidal ideation and behaviour have been reported in patients treated with anti-epileptic agents in several indications.
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Interazioni principali (9)
- Cannabidiol + Sodium valproate Major
- Fosphenytoin + Sodium valproate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Sodium phenylbutyrate + Sodium valproate Major
- Sodium valproate + Vorinostat Major
- Ganaxolone + Sodium valproate Moderate
- Rufinamide + Sodium valproate Moderate
- Sapropterin + Sodium valproate Moderate
- Sodium valproate + Telotristat etiprate Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Altri farmaci della stessa classe
Domande frequenti
What is Sodium valproate used for?
Sodium valproate is a medicine in the class central nervous system. It is used for Epilepsy.
What side effects have been reported with Sodium valproate?
Vomiting, Nausea, Liver injury, Stomatitis, Pancreatitis.
Can Sodium valproate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Major birth-defect risk (about 1 in 10, incl. neural tube defects) and neurodevelopmental problems in up to 30-40% of exposed children. Contraindicated unless no alternative for epilepsy; never for migraine or (EU) bipolar. Specialist review; pregnancy prevention programme. Breastfeeding: Safe. Low levels in milk; usually acceptable. Watch the infant for jaundice, unusual bruising or bleeding; rare cases of low platelets reported.
What does Sodium valproate interact with?
MediHelp lists 9 known interactions for Sodium valproate. Major: 5 · Moderate: 4. The most serious include Cannabidiol, Fosphenytoin, Glycerol phenylbutyrate.
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