Riferimento farmaci
Thyrotropin alfa
Thyrotropin alfa is a medicine in the class endocrine. It is used for thyroid cancer.
- Classe del farmaco: Endocrine
- Indicato per: thyroid cancer
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Endocrine
- Codice ATC
- H01AB01
- Forme farmaceutiche comuni
- iniezione
- Dosaggi comuni
- 0.9 mg/ml
- Nomi commerciali
- 3
- Paesi e mercati
- 3
Per cosa si usa
Come agisce
Thyrotropin alfa binds TSH receptors on normal thyroid epithelial cells or well-differentiated thyroid cancer tissue, stimulating iodine uptake and organification and synthesis and secretion of thyroglobulin, T3 and T4. This increases radioiodine uptake for scan detection or radioiodine killing of thyroid cells.
Dose abituale nell'adulto (sintesi del foglio illustrativo)
Adjunctive diagnostic tool or adjunct for thyroid remnant ablation in well-differentiated thyroid cancer: 0.9 mg intramuscular injection to the buttock, followed by a second 0.9 mg intramuscular injection 24 hours later; intramuscular only, not intravenous
Gravidanza e allattamento
- Gravidanza
- Unsafe Used with radioiodine, it is contraindicated in pregnancy (UK label) because the fetus would be exposed to radiation, which can cause permanent thyroid damage. Data on thyrotropin alfa alone are too few to assess risk; no animal studies. Exclude pregnancy before use.
- Allattamento
- Unsafe With radioiodine: contraindicated (therapy) or stop breastfeeding after the dose (diagnosis), because of radiation to the infant and breast. Alone: no milk data; UK label says do not use while breastfeeding; US label: weigh benefits. Large protein, unlikely to reach the infant.
Effetti indesiderati segnalati
- Nausea
- Headache
- Fatigue
- Vomiting
- Dizziness
- Asthenia
Controindicazioni
- When given with radioiodine, the contraindications to radioiodine also apply to the combination regimen.
- Combination with radioiodine is contraindicated in pregnancy.
- Concomitant use with therapeutic radioiodine is contraindicated in lactating women.
Chi deve prestare attenzione
- Hyperthyroidism: transient significant rise in thyroid hormone in patients with substantial thyroid tissue in situ or functional metastases; deaths reported. Elderly and heart disease patients are at risk; consider hospitalization and observation.
- Stroke reported within 72 hours of administration, mostly in young women taking oral contraceptives or with other stroke risk factors. Ensure patients are well hydrated beforehand.
- Sudden rapid painful tumor enlargement may occur (hemiplegia, hemiparesis, vision loss, laryngeal edema, respiratory distress). Consider glucocorticoid pretreatment.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
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- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Domande frequenti
What is Thyrotropin alfa used for?
Thyrotropin alfa is a medicine in the class endocrine. It is used for Thyroid cancer.
What side effects have been reported with Thyrotropin alfa?
Nausea, Headache, Fatigue, Vomiting, Dizziness, Asthenia.
Can Thyrotropin alfa be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Used with radioiodine, it is contraindicated in pregnancy (UK label) because the fetus would be exposed to radiation, which can cause permanent thyroid damage. Data on thyrotropin alfa alone are too few to assess risk; no animal studies. Exclude pregnancy before use. Breastfeeding: Unsafe. With radioiodine: contraindicated (therapy) or stop breastfeeding after the dose (diagnosis), because of radiation to the infant and breast. Alone: no milk data; UK label says do not use while breastfeeding; US label: weigh benefits. Large protein, unlikely to reach the infant.
What does Thyrotropin alfa interact with?
MediHelp does not list a checked interaction for Thyrotropin alfa yet. Always tell your pharmacist about every medicine you take.
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