Riferimento farmaci
Trifluridine
Trifluridine is a medicine in the class anti virals. It is used for herpes simplex.
- Classe del farmaco: Anti Virals
- Indicato per: herpes simplex
Ultimo aggiornamento Fonti: US FDA label
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In breve
- Classe del farmaco
- Anti Virals
Per cosa si usa
Come agisce
Trifluridine is a fluorinated pyrimidine nucleoside active against herpes simplex virus types 1 and 2. It interferes with DNA synthesis in cultured mammalian cells, but its antiviral mechanism of action is not completely known.
Gravidanza e allattamento
- Gravidanza
- Unsafe Eye drops: little is absorbed; fetal loss only with high injected doses in animals; use only if needed. Oral tablets with tipiracil (Lonsurf, for cancer): can cause fetal harm (fetal deaths in rats at human exposure); avoid and use contraception.
- Allattamento
- Unsafe Eye drops: little is expected in milk; US label: weigh benefits; no LactMed record. Oral tablets with tipiracil (Lonsurf): do not breastfeed during treatment and for 1 day after the last dose.
Effetti indesiderati segnalati
- Burning or stinging upon instillation
- Palpebral edema
- Superficial punctate keratopathy
- Epithelial keratopathy
- Hypersensitivity reaction
- Stromal edema
Controindicazioni
- Patients who develop hypersensitivity reactions or chemical intolerance to trifluridine.
Chi deve prestare attenzione
- The recommended dosage and frequency should not be exceeded.
- Prescribe only for patients with a clinical diagnosis of herpetic keratitis.
- May cause mild, usually transient local irritation of the conjunctiva and cornea.
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- How to give it
- Pharmacokinetics
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Domande frequenti
What is Trifluridine used for?
Trifluridine is a medicine in the class anti virals. It is used for Herpes simplex, Herpetic keratitis.
What side effects have been reported with Trifluridine?
Burning or stinging upon instillation, Palpebral edema, Superficial punctate keratopathy, Epithelial keratopathy, Hypersensitivity reaction, Stromal edema.
Can Trifluridine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Eye drops: little is absorbed; fetal loss only with high injected doses in animals; use only if needed. Oral tablets with tipiracil (Lonsurf, for cancer): can cause fetal harm (fetal deaths in rats at human exposure); avoid and use contraception. Breastfeeding: Unsafe. Eye drops: little is expected in milk; US label: weigh benefits; no LactMed record. Oral tablets with tipiracil (Lonsurf): do not breastfeed during treatment and for 1 day after the last dose.
What does Trifluridine interact with?
MediHelp does not list a checked interaction for Trifluridine yet. Always tell your pharmacist about every medicine you take.
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