Interazioni tra farmaci
Abatacept + Dengue vaccine
Gravità: Maggiore
Abatacept and Dengue vaccine: major interaction.
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Sintesi
Dengue vaccine (Dengvaxia) is a live attenuated vaccine, so it carries a risk of vaccine-related infection in immunosuppressed people. Abatacept may also reduce the immune response to the vaccine.
Cosa significa questa interazione in parole semplici
Abatacept and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perché avviene
Immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
Cosa fare
Avoid live vaccines during abatacept therapy and for several weeks after the last dose, which is roughly 3 months. Consider vaccination before starting treatment.
Cosa chiedere al farmacista
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Altre interazioni di Abatacept
- Abatacept + Adalimumab Maggiore
- Abatacept + Adenovirus types 4 and 7 live Maggiore
- Abatacept + Anakinra Maggiore
- Abatacept + Baricitinib Maggiore
- Abatacept + Belatacept Maggiore
- Abatacept + Certolizumab pegol Maggiore
Domande frequenti
Can I take Abatacept with Dengue vaccine?
MediHelp rates the interaction as major. Abatacept and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine (Dengvaxia) is a live attenuated vaccine, so it carries a risk of vaccine-related infection in immunosuppressed people. Abatacept may also reduce the immune response to the vaccine.
How serious is the interaction between Abatacept and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during abatacept therapy and for several weeks after the last dose, which is roughly 3 months. Consider vaccination before starting treatment.
What other medicines interact with Abatacept?
MediHelp also lists interactions of Abatacept with, for example, Adalimumab, Adenovirus types 4 and 7 live, Anakinra. The full list is on the Abatacept page.
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